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Document type:
journal article 
Author(s):
Rudolph, C; Schillinger, U; Ortiz, A; Tabatt, K; Plank, C; Müller, RH; Rosenecker, J 
Title:
Application of novel solid lipid nanoparticle (SLN)-gene vector formulations based on a dimeric HIV-1 TAT-peptide in vitro and in vivo. 
Abstract:
PURPOSE: To optimize gene delivery of SLN-based gene vectors by incorporation of a dimeric HIV-1 TAT peptide (TAT2) into SLN gene vectors. METHODS: Plasmid DNA was complexed with two SLN preparations either with or without pre-compaction of DNA by TAT2, poly-L-arginine, or the mutant TAT2-M1. DNA complexed with polyethylenimine (PEI) served as a standard. Gene expression was analyzed upon transfection of bronchial epithelial cells in vitro and after intratracheal instillation or aerosol applicat...    »
 
Journal title abbreviation:
Pharm Res 
Year:
2004 
Journal volume:
21 
Journal issue:
Pages contribution:
1662-9 
Language:
eng 
Print-ISSN:
0724-8741 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung