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Document type:
journal article 
Author(s):
Krötz, F; de Wit, C; Sohn, HY; Zahler, S; Gloe, T; Pohl, U; Plank, C 
Title:
Magnetofection--a highly efficient tool for antisense oligonucleotide delivery in vitro and in vivo. 
Abstract:
Delivery of antisense oligodesoxynucleotides (ODN) into primary cells is a specific strategy for research with therapeutic perspectives but transfection-associated difficulties. We established the technique of magnetofection to enhance ODN delivery at low toxicity and procedure time in vitro and in vivo. In vitro, target knockout was assessed at protein and mRNA levels and by measuring superoxide generation after antisense magnetofection against the p22(phox) subunit of endothelial NAD(P)H-oxida...    »
 
Journal title abbreviation:
Mol Ther 
Year:
2003 
Journal volume:
Journal issue:
5 Pt 1 
Pages contribution:
700-10 
Language:
eng 
Print-ISSN:
1525-0016 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung