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Dokumenttyp:
journal article 
Autor(en):
Banke, IJ; Arlt, MJ; Pennington, C; Kopitz, C; Steinmetzer, T; Schweinitz, A; Gansbacher, B; Quigley, JP; Edwards, DR; Stürzebecher, J; Krüger, A 
Titel:
Increase of anti-metastatic efficacy by selectivity- but not affinity-optimization of synthetic serine protease inhibitors. 
Abstract:
Although tumors frequently show elevated protease activities, the concept of anti-proteolytic cancer therapy has lost momentum after failure of clinical trials with broad-spectrum matrix metalloproteinase inhibitors. Thus we need to adapt our design strategies for protease inhibitors. Here, we employed a series of seven structurally fine-modulated and pharmacokinetically closely related synthetic 4-amidinobenzylamine-based inhibitors with distinct selectivity for prototypical serine proteases in...    »
 
Zeitschriftentitel:
Biol Chem 
Jahr:
2003 
Band / Volume:
384 
Heft / Issue:
10-11 
Seitenangaben Beitrag:
1515-25 
Sprache:
eng 
Print-ISSN:
1431-6730 
TUM Einrichtung:
r experimentelle Onkologie und Therapieforschung