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Document type:
journal article 
Author(s):
Bengel, FM; Anton, M; Richter, T; Simoes, MV; Haubner, R; Henke, J; Erhardt, W; Reder, S; Lehner, T; Brandau, W; Boekstegers, P; Nekolla, SG; Gansbacher, B; Schwaiger, M 
Title:
Noninvasive imaging of transgene expression by use of positron emission tomography in a pig model of myocardial gene transfer. 
Abstract:
BACKGROUND: Radionuclide imaging of reporter gene expression may be useful for noninvasive monitoring of clinical cardiac gene therapy. Experience until now, however, has been limited to small animals. METHODS AND RESULTS: To evaluate feasibility in a clinically applicable setting, pigs were studied by conventional positron emission tomography (PET) 2 days after regional intramyocardial injection of control adenovirus or adenovirus carrying herpesviral thymidine kinase reporter gene (HSV1-tk). M...    »
 
Journal title abbreviation:
Circulation 
Year:
2003 
Journal volume:
108 
Journal issue:
17 
Pages contribution:
2127-33 
Language:
eng 
Print-ISSN:
0009-7322 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik; r experimentelle Onkologie und Therapieforschung