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Dokumenttyp:
journal article 
Autor(en):
Holm, PS; Bergmann, S; Jurchott, K; Lage, H; Brand, K; Ladhoff, A; Mantwill, K; Curiel, DT; Dobbelstein, M; Dietel, M; Gansbacher, B; Royer, HD 
Titel:
YB-1 relocates to the nucleus in adenovirus-infected cells and facilitates viral replication by inducing E2 gene expression through the E2 late promoter. 
Abstract:
The adenovirus early proteins E1A and E1B-55kDa are key regulators of viral DNA replication, and it was thought that targeting of p53 by E1B-55kDa is essential for this process. Here we have identified a previously unrecognized function of E1B for adenovirus replication. We found that E1B-55kDa is involved in targeting the transcription factor YB-1 to the nuclei of adenovirus type 5-infected cells where it is associated with viral inclusion bodies believed to be sites of viral transcription and...    »
 
Zeitschriftentitel:
J Biol Chem 
Jahr:
2002 
Band / Volume:
277 
Heft / Issue:
12 
Seitenangaben Beitrag:
10427-34 
Sprache:
eng 
Print-ISSN:
0021-9258 
TUM Einrichtung:
r experimentelle Onkologie und Therapieforschung