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Dokumenttyp:
journal article 
Autor(en):
Sato, S; Kopitz, C; Schmalix, WA; Muehlenweg, B; Kessler, H; Schmitt, M; Krüger, A; Magdolen, V 
Titel:
High-affinity urokinase-derived cyclic peptides inhibiting urokinase/urokinase receptor-interaction: effects on tumor growth and spread. 
Abstract:
Urokinase-type plasminogen activator (uPA) binds with high affinity to its specific cell surface receptor (uPAR) (CD87) via a well-defined sequence within the N-terminal region of uPA (uPA(19-31)). Since this uPA/uPAR-interaction plays a significant role in tumor cell invasion and metastasis, it has become an attractive therapeutic target. Two small peptidic cyclic competitive antagonists of uPA/uPAR-interaction have been developed, based on the uPAR binding site in uPA: WX-360 (cyclo(21,29)[D-C...    »
 
Zeitschriftentitel:
FEBS Lett 
Jahr:
2002 
Band / Volume:
528 
Heft / Issue:
1-3 
Seitenangaben Beitrag:
212-6 
Sprache:
eng 
Print-ISSN:
0014-5793 
TUM Einrichtung:
r experimentelle Onkologie und Therapieforschung