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Document type:
journal article 
Author(s):
Haubner, R; Weber, WA; Beer, AJ; Vabuliene, E; Reim, D; Sarbia, M; Becker, KF; Goebel, M; Hein, R; Wester, HJ; Kessler, H; Schwaiger, M 
Title:
Noninvasive visualization of the activated alpha v beta 3 integrin in cancer patients by positron emission tomography and [F-18]Galacto-RGD 
Abstract:
Background The integrin alpha v beta 3 plays an important role in angiogenesis and tumor cell metastasis, and is currently being evaluated as a target for new therapeutic approaches. Several techniques are being studied to enable noninvasive determination of alpha v beta 3 expression. We developed [F-18]Galacto-RGD, a F-18-labeled glycosylated alpha v beta 3 antagonist, allowing monitoring of alpha v beta 3 expression with positron emission tomography (PET). Methods and Findings Here we show by...    »
 
Journal title abbreviation:
PLoS Med 
Year:
2005 
Journal volume:
Journal issue:
Pages contribution:
244-252 
Language:
eng 
Print-ISSN:
1549-1277 
TUM Institution:
Institut für Radiologie ; Institut für Allgemeine Pathologie und pathologische Anatomie ; Klinik und Poliklinik für Dermatologie und Allergologie ; Nuklearmedizinische Klinik und Poliklinik