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Dokumenttyp:
journal article 
Autor(en):
Martini, M; Gnann, A; Scheikl, D; Holzmann, B; Janssen, KP 
Titel:
The candidate tumor suppressor SASH1 interacts with the actin cytoskeleton and stimulates cell-matrix adhesion. 
Abstract:
SASH1, a member of the SLY-family of signal adapter proteins, is a candidate tumor suppressor in breast and colon cancer. Reduced expression of SASH1 is correlated with aggressive tumor growth, metastasis formation, and inferior prognosis. However, the biological role of SASH1 remains largely unknown. To unravel the function of SASH1, we have analyzed the intracellular localization of endogenous SASH1, and have generated structural SASH1 mutants. SASH1 localized to the nucleus as well as to the...    »
 
Zeitschriftentitel:
Int J Biochem Cell Biol 
Jahr:
2011 
Band / Volume:
43 
Heft / Issue:
11 
Seitenangaben Beitrag:
1630-40 
Sprache:
eng 
Print-ISSN:
1357-2725 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik