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Dokumenttyp:
journal article 
Autor(en):
Reim, D; Rossmann-Bloeck, T; Jusek, G; Prazeres da Costa, O; Holzmann, B 
Titel:
Improved host defense against septic peritonitis in mice lacking MyD88 and TRIF is linked to a normal interferon response. 
Abstract:
The signaling adapters MyD88 and TRIF are engaged by TLRs and/or receptors of the IL-1 family and are considered important for innate immune responses that combat bacterial infections. Here, the consequences of a combined MyD88 and TRIF deficiency for the innate immune response against severe septic peritonitis was examined. We demonstrate that Myd88(-/-); Trif(Lps2/Lps2) mice had markedly reduced bacterial numbers in the peritoneal cavity and peripheral blood, indicating that bacterial clearanc...    »
 
Zeitschriftentitel:
J Leukoc Biol 
Jahr:
2011 
Band / Volume:
90 
Heft / Issue:
Seitenangaben Beitrag:
613-20 
Sprache:
eng 
Print-ISSN:
0741-5400 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik; r Medizinische Mikrobiologie, Immunologie und Hygiene