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Dokumenttyp:
journal article 
Autor(en):
Weber, GF; Gaertner, FC; Erl, W; Janssen, KP; Blechert, B; Holzmann, B; Weighardt, H; Essler, M 
Titel:
IL-22-Mediated Tumor Growth Reduction Correlates with Inhibition of ERK1/2 and AKT Phosphorylation and Induction of Cell Cycle Arrest in the G2-M Phase. 
Abstract:
IL-22 is a recently discovered cytokine of the IL-10 family that binds to a class II cytokine receptor composed of IL-22R1 and IL-10R2(c) and influences a variety of immune reactions. As IL-22 has also been shown to modulate cell cycle and proliferation mediators such as ERK1/2 and JNK, we studied the role of IL-22 in proliferation, apoptosis, and cell cycle regulation in EMT6 murine breast cancer cells in vitro and in vivo. In this study, we report that murine breast cancer cells express functi...    »
 
Zeitschriftentitel:
J Immunol 
Jahr:
2006 
Band / Volume:
177 
Heft / Issue:
11 
Seitenangaben Beitrag:
8266-72 
Sprache:
eng 
Print-ISSN:
0022-1767 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik; Nuklearmedizinische Klinik und Poliklinik