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Dokumenttyp:
journal article 
Autor(en):
Weighardt, H; Kaiser-Moore, S; Schlautkötter, S; Rossmann-Bloeck, T; Schleicher, U; Bogdan, C; Holzmann, B 
Titel:
Type I IFN modulates host defense and late hyperinflammation in septic peritonitis. 
Abstract:
TLRs are considered important for the control of immune responses during endotoxic shock or polymicrobial sepsis. Signaling by TLRs may proceed through the adapter proteins MyD88 or TIR domain-containing adaptor inducinng IFN-beta. Both pathways can lead to the production of type I IFNs (IFN-alphabeta). In the present study, the role of the type I IFN pathway for host defense and immune pathology in sepsis was investigated using a model of mixed bacterial peritonitis. Systemic levels of IFN-alph...    »
 
Zeitschriftentitel:
J Immunol 
Jahr:
2006 
Band / Volume:
177 
Heft / Issue:
Seitenangaben Beitrag:
5623-30 
Sprache:
eng 
Print-ISSN:
0022-1767 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik