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Document type:
journal article 
Author(s):
Feterowski, C; Mack, M; Weighardt, H; Bartsch, B; Kaiser-Moore, S; Holzmann, B 
Title:
CC chemokine receptor 2 regulates leukocyte recruitment and IL-10 production during acute polymicrobial sepsis. 
Abstract:
Chemokine receptors are important for recruiting leukocytes to sites of infection and may contribute to immune cell activation. The present study investigated the role of the chemokine receptor CCR2 in polymicrobial septic peritonitis. The results showed that peritoneal production of the CCR2 ligands CCL2 and CCL12 in septic mice was largely independent of the common Toll-like receptor signaling adaptor MyD88. Antibody blockade of CCR2 reduced the recruitment of macrophages and neutrophils to th...    »
 
Journal title abbreviation:
Eur J Immunol 
Year:
2004 
Journal volume:
34 
Journal issue:
12 
Pages contribution:
3664-73 
Language:
eng 
Print-ISSN:
0014-2980 
TUM Institution:
Chirurgiesche Klinik und Poliklinik