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Dokumenttyp:
journal article 
Autor(en):
Wang, XD; Rammes, G; Kraev, I; Wolf, M; Liebl, C; Scharf, SH; Rice, CJ; Wurst, W; Holsboer, F; Deussing, JM; Baram, TZ; Stewart, MG; Müller, MB; Schmidt, MV 
Titel:
Forebrain CRF? modulates early-life stress-programmed cognitive deficits. 
Abstract:
Childhood traumatic events hamper the development of the hippocampus and impair declarative memory in susceptible individuals. Persistent elevations of hippocampal corticotropin-releasing factor (CRF), acting through CRF receptor 1 (CRF?), in experimental models of early-life stress have suggested a role for this endogenous stress hormone in the resulting structural modifications and cognitive dysfunction. However, direct testing of this possibility has been difficult. In the current study, we s...    »
 
Zeitschriftentitel:
J Neurosci 
Jahr:
2011 
Band / Volume:
31 
Heft / Issue:
38 
Seitenangaben Beitrag:
13625-34 
Sprache:
eng 
Print-ISSN:
0270-6474 
TUM Einrichtung:
sthesiologie