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Document type:
journal article 
Author(s):
Bissinger, Oliver; Kreutzer, Kilian; Wolff, Klaus-Dietrich; Wexel, Gabriele; Hapfelmeier, Alexander; Pautke, Christoph; Vogt, Stephan; Michael Prodinger, Peter; Tischer, Thomas 
Title:
Does cefuroxime alter fracture healing in vivo? A micro-computertomographic, biomechanical, and histomorphometric evaluation using a rat fracture model. 
Abstract:
Cefuroxime is widely used for antibiotic prophylaxis in orthopedic surgery. However, a recent study indicated a dose-dependent reduction in osteoblast function in vitro. Nevertheless, cell culture might not sufficiently imitate the complex process of bone remodeling. As data concerning possible in vivo interactions of cefuroxime on fracture healing are completely missing, we investigated the following hypothesis: Does Cefuroxime impair bone healing in vivo? Therefore, 34 male Wistar rats were ra...    »
 
Journal title abbreviation:
J Biomed Mater Res B Appl Biomater 
Year:
2017 
Journal volume:
105 
Journal issue:
Pages contribution:
2282-2291 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
1552-4973 
TUM Institution:
Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie; Institut für Medizinische Informatik, Statistik und Epidemiologie