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Document type:
journal article 
Author(s):
Press, Adrian T; Traeger, Anja; Pietsch, Christian; Mosig, Alexander; Wagner, Michael; Clemens, Mark G; Jbeily, Nayla; Koch, Nicole; Gottschaldt, Michael; Bézière, Nicolas; Ermolayev, Volodymyr; Ntziachristos, Vasilis; Popp, Jürgen; Kessels, Michael M; Qualmann, Britta; Schubert, Ulrich S; Bauer, Michael 
Title:
Cell type-specific delivery of short interfering RNAs by dye-functionalised theranostic nanoparticles. 
Abstract:
Efficient delivery of short interfering RNAs reflects a prerequisite for the development of RNA interference therapeutics. Here, we describe highly specific nanoparticles, based on near infrared fluorescent polymethine dye-derived targeting moieties coupled to biodegradable polymers. The fluorescent dye, even when coupled to a nanoparticle, mimics a ligand for hepatic parenchymal uptake transporters resulting in hepatobiliary clearance of approximately 95% of the dye within 45 min. Body distribu...    »
 
Journal title abbreviation:
Nat Commun 
Year:
2014 
Journal volume:
Pages contribution:
5565 
Language:
eng 
TUM Institution:
Lehrstuhl für Biologische Bildgebung