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Dokumenttyp:
journal article 
Autor(en):
Sorbara, Catherine Diamante; Wagner, Naomi Elizabeth; Ladwig, Anne; Niki?, Ivana; Merkler, Doron; Kleele, Tatjana; Marinkovi?, Petar; Naumann, Ronald; Godinho, Leanne; Bareyre, Florence Martine; Bishop, Derron; Misgeld, Thomas; Kerschensteiner, Martin 
Titel:
Pervasive axonal transport deficits in multiple sclerosis models. 
Abstract:
Impaired axonal transport can contribute to axon degeneration and has been described in many neurodegenerative diseases. Multiple sclerosis (MS) is a common neuroinflammatory disease, which is characterized by progressive axon degeneration-whether, when, and how axonal transport is affected in this condition is unknown. Here we used in vivo two-photon imaging to directly assay transport of organelles and the stability of microtubule tracks in individual spinal axons in mouse models of MS. We fou...    »
 
Zeitschriftentitel:
Neuron 
Jahr:
2014 
Band / Volume:
84 
Heft / Issue:
Seitenangaben Beitrag:
1183-90 
Sprache:
eng 
Print-ISSN:
0896-6273 
TUM Einrichtung:
Institut für Zellbiologie des Nervensystems