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Dokumenttyp:
journal article 
Autor(en):
Brampton, Christopher; Aherrahrou, Zouhair; Chen, Li-Hsieh; Martin, Ludovic; Bergen, Arthur A B; Gorgels, Theo G M F; Erdmann, Jeannette; Erdfdi, Jeannette; Schunkert, Heribert; Szabó, Zalán; Váradi, András; Le Saux, Olivier 
Titel:
The level of hepatic ABCC6 expression determines the severity of calcification after cardiac injury. 
Abstract:
Because vascular or cardiac mineralization is inversely correlated with morbidity and long-term survival, we investigated the role of ABCC6 in the calcification response to cardiac injury in mice. By using two models of infarction, nonischemic cryoinjury and the pathologically relevant coronary artery ligation, we confirmed a large propensity to acute cardiac mineralization in Abcc6-/- mice. Furthermore, when the expression of ABCC6 was reduced to approximately 38% of wild-type levels in Abcc6+/...    »
 
Zeitschriftentitel:
Am J Pathol 
Jahr:
2014 
Band / Volume:
184 
Heft / Issue:
Seitenangaben Beitrag:
159-70 
Sprache:
eng 
Print-ISSN:
0002-9440 
TUM Einrichtung:
Klinik für Herz- und Kreislauferkrankungen