Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Miller, Clint L; Haas, Ulrike; Diaz, Roxanne; Leeper, Nicholas J; Kundu, Ramendra K; Patlolla, Bhagat; Assimes, Themistocles L; Kaiser, Frank J; Perisic, Ljubica; Hedin, Ulf; Maegdefessel, Lars; Schunkert, Heribert; Erdmann, Jeanette; Quertermous, Thomas; Sczakiel, Georg 
Titel:
Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation. 
Abstract:
Genome-wide association studies (GWAS) have identified chromosomal loci that affect risk of coronary heart disease (CHD) independent of classical risk factors. One such association signal has been identified at 6q23.2 in both Caucasians and East Asians. The lead CHD-associated polymorphism in this region, rs12190287, resides in the 3' untranslated region (3'-UTR) of TCF21, a basic-helix-loop-helix transcription factor, and is predicted to alter the seed binding sequence for miR-224. Allelic imba...    »
 
Zeitschriftentitel:
PLoS Genet 
Jahr:
2014 
Band / Volume:
10 
Heft / Issue:
Seitenangaben Beitrag:
e1004263 
Sprache:
eng 
Print-ISSN:
1553-7390 
TUM Einrichtung:
Klinik für Herz- und Kreislauferkrankungen