User: Guest  Login
Document type:
journal article 
Author(s):
Paul, Dirk S; Albers, Cornelis A; Rendon, Augusto; Voss, Katrin; Stephens, Jonathan; HaemGen Consortium; van der Harst, Pim; Chambers, John C; Soranzo, Nicole; Ouwehand, Willem H; Deloukas, Panos; Akkerman, Jan-Willem N; Albers, Cornelis A; Algra, Ale; Al-Hussani, Abtehale; Allayee, Hooman; Anni, Franco; Asselbergs, Folkert W; Attwood, Antony; Balkau, Beverley; Bandinelli, Stefania; Bastardot, François; Basu, Saonli; Baumeister, Sebastian E; Beckmann, Jacques; Benyamin, Beben; Biino, Ginevra; Bi...    »
 
Title:
Maps of open chromatin highlight cell type-restricted patterns of regulatory sequence variation at hematological trait loci. 
Abstract:
Nearly three-quarters of the 143 genetic signals associated with platelet and erythrocyte phenotypes identified by meta-analyses of genome-wide association (GWA) studies are located at non-protein-coding regions. Here, we assessed the role of candidate regulatory variants associated with cell type-restricted, closely related hematological quantitative traits in biologically relevant hematopoietic cell types. We used formaldehyde-assisted isolation of regulatory elements followed by next-generati...    »
 
Journal title abbreviation:
Genome Res 
Year:
2013 
Journal volume:
23 
Journal issue:
Pages contribution:
1130-41 
Language:
eng 
Print-ISSN:
1088-9051 
TUM Institution:
Klinik für Herz- und Kreislauferkrankungen