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Dokumenttyp:
journal article 
Autor(en):
Oeder, S; Alessandrini, F; Wirz, O F; Braun, A; Wimmer, M; Frank, U; Hauser, M; Durner, J; Ferreira, F; Ernst, D; Mempel, M; Gilles, S; Buters, J T M; Behrendt, H; Traidl-Hoffmann, C; Schmidt-Weber, C; Akdis, M; Gutermuth, J 
Titel:
Pollen-derived nonallergenic substances enhance Th2-induced IgE production in B cells. 
Abstract:
B cells play a central role in IgE-mediated allergies. In damaged airway epithelium, they are exposed directly to aeroallergens. We aimed to assess whether direct exposure of B cells to pollen constituents affects allergic sensitization.B cells from murine splenocytes and from blood samples of healthy donors were incubated for 8 days under Th2-like conditions with aqueous ragweed pollen extracts (Amb-APE) or its constituents. Secreted total IgM, IgG, and IgE was quantified by ELISA. Additionally...    »
 
Zeitschriftentitel:
Allergy 
Jahr:
2015 
Band / Volume:
70 
Heft / Issue:
11 
Seitenangaben Beitrag:
1450-60 
Sprache:
eng 
Print-ISSN:
0105-4538 
TUM Einrichtung:
Institut für Molekulare Allergologie und Umweltforschung