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Document type:
journal article 
Author(s):
Kreymborg, Katharina; Haak, Stefan; Murali, Rajmohan; Wei, Joyce; Waitz, Rebecca; Gasteiger, Georg; Savage, Peter A; van den Brink, Marcel R M; Allison, James P 
Title:
Ablation of B7-H3 but Not B7-H4 Results in Highly Increased Tumor Burden in a Murine Model of Spontaneous Prostate Cancer. 
Abstract:
The costimulatory molecules B7-H3 and B7-H4 are overexpressed in a variety of human tumors and have been hypothesized as possible biomarkers and immunotherapeutic targets. Despite this potential, the predominating uncertainty about their functional implication in tumor-host interaction hampers their evaluation as a target for cancer therapy. By means of a highly physiologic, spontaneous tumor model in mice, we establish a causal link between B7-H3 and host tumor control and found B7-H4 to be red...    »
 
Journal title abbreviation:
Cancer Immunol Res 
Year:
2015 
Journal volume:
Journal issue:
Pages contribution:
849-54 
Language:
eng 
Print-ISSN:
2326-6066 
TUM Institution:
Institut für Molekulare Allergologie und Umweltforschung