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Dokumenttyp:
journal article 
Autor(en):
Okiyama, Naoko; Furumoto, Yasuko; Villarroel, Vadim A; Linton, Jay T; Tsai, Wanxia L; Gutermuth, Jan; Ghoreschi, Kamran; Gadina, Massimo; O'Shea, John J; Katz, Stephen I 
Titel:
Reversal of CD8 T-Cell-mediated mucocutaneous graft-versus-host-like disease by the JAK inhibitor tofacitinib. 
Abstract:
The utility of allogeneic hematopoietic stem cell transplantation is limited by graft-versus-host disease (GVHD), a significant cause of morbidity and mortality. Patients with GVHD exhibit cutaneous manifestations with histological features of interface dermatitis followed by scleroderma-like changes. JAK inhibitors represent a class of immunomodulatory drugs that inhibit signaling by multiple cytokines. Herein we report the effects of tofacitinib in a murine model of GVHD. Oral administration o...    »
 
Zeitschriftentitel:
J Invest Dermatol 
Jahr:
2014 
Band / Volume:
134 
Heft / Issue:
Seitenangaben Beitrag:
992-1000 
Sprache:
eng 
Print-ISSN:
0022-202X 
TUM Einrichtung:
Institut für Molekulare Allergologie und Umweltforschung