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Dokumenttyp:
journal article 
Autor(en):
Granzow, Michaela; Schierwagen, Robert; Klein, Sabine; Kowallick, Benita; Huss, Sebastian; Linhart, Markus; Mazar, Irela G Reza; Görtzen, Jan; Vogt, Annabelle; Schildberg, Frank A; Gonzalez-Carmona, Maria A; Wojtalla, Alexandra; Krämer, Benjamin; Nattermann, Jacob; Siegmund, Sören V; Werner, Nikos; Fürst, Dieter O; Laleman, Wim; Knolle, Percy; Shah, Vijay H; Sauerbruch, Tilman; Trebicka, Jonel 
Titel:
Angiotensin-II type 1 receptor-mediated Janus kinase 2 activation induces liver fibrosis. 
Abstract:
Activation of the renin angiotensin system resulting in stimulation of angiotensin-II (AngII) type I receptor (AT1R) is an important factor in the development of liver fibrosis. Here, we investigated the role of Janus kinase 2 (JAK2) as a newly described intracellular effector of AT1R in mediating liver fibrosis. Fibrotic liver samples from rodents and humans were compared to respective controls. Transcription, protein expression, activation, and localization of JAK2 and downstream effectors wer...    »
 
Zeitschriftentitel:
Hepatology 
Jahr:
2014 
Band / Volume:
60 
Heft / Issue:
Seitenangaben Beitrag:
334-48 
Sprache:
eng 
Print-ISSN:
0270-9139 
TUM Einrichtung:
Institut für Molekulare Immunologie