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Document type:
journal article 
Author(s):
Niño-Castro, Andrea; Abdullah, Zeinab; Popov, Alexey; Thabet, Yasser; Beyer, Marc; Knolle, Percy; Domann, Eugen; Chakraborty, Trinad; Schmidt, Susanne V; Schultze, Joachim L 
Title:
The IDO1-induced kynurenines play a major role in the antimicrobial effect of human myeloid cells against Listeria monocytogenes. 
Abstract:
Induction of indoleamine 2,3-dioxygenase (IDO1) is an established cellular response to infection with numerous pathogens. Several mechanisms, such as IDO1-mediated tryptophan (Trp) depletion, but also accumulation of Trp catabolites, have been associated with the antimicrobial effects of IDO(+) cells. Recent findings of IDO1 as an immunoinhibitory and signaling molecule extended these previous observations. Using infection of professional phagocytes with Listeria monocytogenes (L.m.) as a model,...    »
 
Journal title abbreviation:
Innate Immun 
Year:
2014 
Journal volume:
20 
Journal issue:
Pages contribution:
401-11 
Language:
eng 
Print-ISSN:
1753-4259 
TUM Institution:
Institut für Molekulare Immunologie