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Dokumenttyp:
journal article 
Autor(en):
Wu, Yonghe; Tedesco, Lucas; Lucia, Kristin; Schlitter, Anna M; Garcia, Jose Monteserin; Esposito, Irene; Auernhammer, Christoph J; Theodoropoulou, Marily; Arzt, Eduardo; Renner, Ulrich; Stalla, Günter K 
Titel:
RSUME is implicated in tumorigenesis and metastasis of pancreatic neuroendocrine tumors. 
Abstract:
The factors triggering pancreatic neuroendocrine tumor (PanNET) progression are largely unknown. Here we investigated the role and mechanisms of the sumoylation enhancing protein RSUME in PanNET tumorigenesis. Immunohistochemical studies showed that RSUME is strongly expressed in normal human pancreas, in particular in ?-cells. RSUME expression is reduced in insulinomas and is nearly absent in other types of PanNETs suggesting a role in PanNET tumorigenesis. In human pancreatic neuroendocrine BO...    »
 
Zeitschriftentitel:
Oncotarget 
Jahr:
2016 
Band / Volume:
Heft / Issue:
36 
Seitenangaben Beitrag:
57878-57893 
Sprache:
eng 
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie