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Document type:
journal article 
Author(s):
Brampton, Christopher; Aherrahrou, Zouhair; Chen, Li-Hsieh; Martin, Ludovic; Bergen, Arthur A B; Gorgels, Theo G M F; Erdmann, Jeannette; Erdfdi, Jeannette; Schunkert, Heribert; Szabó, Zalán; Váradi, András; Le Saux, Olivier 
Title:
The level of hepatic ABCC6 expression determines the severity of calcification after cardiac injury. 
Abstract:
Because vascular or cardiac mineralization is inversely correlated with morbidity and long-term survival, we investigated the role of ABCC6 in the calcification response to cardiac injury in mice. By using two models of infarction, nonischemic cryoinjury and the pathologically relevant coronary artery ligation, we confirmed a large propensity to acute cardiac mineralization in Abcc6-/- mice. Furthermore, when the expression of ABCC6 was reduced to approximately 38% of wild-type levels in Abcc6+/...    »
 
Journal title abbreviation:
Am J Pathol 
Year:
2014 
Journal volume:
184 
Journal issue:
Pages contribution:
159-70 
Language:
eng 
Print-ISSN:
0002-9440 
TUM Institution:
Klinik für Herz- und Kreislauferkrankungen