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Dokumenttyp:
journal article 
Autor(en):
Beyer, Marc; Abdullah, Zeinab; Chemnitz, Jens M; Maisel, Daniela; Sander, Jil; Lehmann, Clara; Thabet, Yasser; Shinde, Prashant V; Schmidleithner, Lisa; Köhne, Maren; Trebicka, Jonel; Schierwagen, Robert; Hofmann, Andrea; Popov, Alexey; Lang, Karl S; Oxenius, Annette; Buch, Thorsten; Kurts, Christian; Heikenwalder, Mathias; Fätkenheuer, Gerd; Lang, Philipp A; Hartmann, Pia; Knolle, Percy A; Schultze, Joachim L 
Titel:
Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infection. 
Abstract:
Persistent viral infections are characterized by the simultaneous presence of chronic inflammation and T cell dysfunction. In prototypic models of chronicity-infection with human immunodeficiency virus (HIV) or lymphocytic choriomeningitis virus (LCMV)-we used transcriptome-based modeling to reveal that CD4(+) T cells were co-exposed not only to multiple inhibitory signals but also to tumor-necrosis factor (TNF). Blockade of TNF during chronic infection with LCMV abrogated the inhibitory gene-ex...    »
 
Zeitschriftentitel:
Nat Immunol 
Jahr:
2016 
Band / Volume:
17 
Heft / Issue:
Seitenangaben Beitrag:
593-603 
Sprache:
eng 
Print-ISSN:
1529-2908 
TUM Einrichtung:
Institut für Virologie; Institut für Molekulare Immunologie