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Dokumenttyp:
journal article 
Autor(en):
Roblek, Marko; Strutzmann, Elisabeth; Zankl, Christina; Adage, Tiziana; Heikenwalder, Mathias; Atlic, Aid; Weis, Roland; Kungl, Andreas; Borsig, Lubor 
Titel:
Targeting of CCL2-CCR2-Glycosaminoglycan Axis Using a CCL2 Decoy Protein Attenuates Metastasis through Inhibition of Tumor Cell Seeding. 
Abstract:
The CCL2-CCR2 chemokine axis has an important role in cancer progression where it contributes to metastatic dissemination of several cancer types (e.g., colon, breast, prostate). Tumor cell-derived CCL2 was shown to promote the recruitment of CCR2(+)/Ly6C(hi) monocytes and to induce vascular permeability of CCR2(+) endothelial cells in the lungs. Here we describe a novel decoy protein consisting of a CCL2 mutant protein fused to human serum albumin (dnCCL2-HSA chimera) with enhanced binding affi...    »
 
Zeitschriftentitel:
Neoplasia 
Jahr:
2016 
Band / Volume:
18 
Heft / Issue:
Seitenangaben Beitrag:
49-59 
Sprache:
eng 
Print-ISSN:
1522-8002 
TUM Einrichtung:
Institut für Virologie