Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Matter, Matthias S; Marquardt, Jens U; Andersen, Jesper B; Quintavalle, Cristina; Korokhov, Nikolay; Stauffer, Jim K; Kaji, Kosuke; Decaens, Thomas; Quagliata, Luca; Elloumi, Fathi; Hoang, Tanya; Molinolo, Alfredo; Conner, Elizabeth A; Weber, Achim; Heikenwalder, Matthias; Factor, Valentina M; Thorgeirsson, Snorri S 
Titel:
Oncogenic driver genes and the inflammatory microenvironment dictate liver tumor phenotype. 
Abstract:
The majority of hepatocellular carcinoma develops in the background of chronic liver inflammation caused by viral hepatitis and alcoholic or nonalcoholic steatohepatitis. However, the impact of different types of chronic inflammatory microenvironments on the phenotypes of tumors generated by distinct oncogenes is largely unresolved. To address this issue, we generated murine liver tumors by constitutively active AKT-1 (AKT) and ?-catenin (CAT), followed by induction of chronic liver inflammation...    »
 
Zeitschriftentitel:
Hepatology 
Jahr:
2016 
Band / Volume:
63 
Heft / Issue:
Seitenangaben Beitrag:
1888-99 
Sprache:
eng 
Print-ISSN:
0270-9139 
TUM Einrichtung:
Institut für Virologie