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Dokumenttyp:
journal article 
Autor(en):
Berscheminski, J; Brun, J; Speiseder, T; Wimmer, P; Ip, W H; Terzic, M; Dobner, T; Schreiner, S 
Titel:
Sp100A is a tumor suppressor that activates p53-dependent transcription and counteracts E1A/E1B-55K-mediated transformation. 
Abstract:
Human adenoviruses (HAdV) are used as a model system to investigate tumorigenic processes in mammalian cells where the viral oncoproteins E1A and E1B-55K are absolutely required for oncogenic transformation, because they simultaneously accelerate cell cycle progression and inhibit tumor suppressor proteins such as p53, although the underlying mechanism is still not understood in detail. In our present study, we provide evidence that E1B-55K binding to the PML-NB component Sp100A apparently has a...    »
 
Zeitschriftentitel:
Oncogene 
Jahr:
2016 
Band / Volume:
35 
Heft / Issue:
24 
Seitenangaben Beitrag:
3178-89 
Sprache:
eng 
Print-ISSN:
0950-9232 
TUM Einrichtung:
Institut für Virologie