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Dokumenttyp:
journal article 
Autor(en):
Petrylak, Daniel P; Vogelzang, Nicholas J; Budnik, Nikolay; Wiechno, Pawel Jan; Sternberg, Cora N; Doner, Kevin; Bellmunt, Joaquim; Burke, John M; de Olza, Maria Ochoa; Choudhury, Ananya; Gschwend, Juergen E; Kopyltsov, Evgeny; Flechon, Aude; Van As, Nicolas; Houede, Nadine; Barton, Debora; Fandi, Abderrahim; Jungnelius, Ulf; Li, Shaoyi; de Wit, Ronald; Fizazi, Karim 
Titel:
Docetaxel and prednisone with or without lenalidomide in chemotherapy-naive patients with metastatic castration-resistant prostate cancer (MAINSAIL): a randomised, double-blind, placebo-controlled phase 3 trial. 
Abstract:
Patients with metastatic castration-resistant prostate cancer have few treatment options. We investigated the safety and efficacy of lenalidomide, an immunomodulatory agent with anti-angiogenic properties, in combination with docetaxel and prednisone in chemotherapy-naive patients with metastatic castration-resistant prostate cancer.In this randomised, double-blind, placebo-controlled, phase 3 study, we randomly assigned chemotherapy-naive patients with progressive metastatic castration-resistan...    »
 
Zeitschriftentitel:
Lancet Oncol 
Jahr:
2015 
Band / Volume:
16 
Heft / Issue:
Seitenangaben Beitrag:
417-25 
Sprache:
eng 
Print-ISSN:
1470-2045 
TUM Einrichtung:
Urologische Klinik und Poliklinik