Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Keller, Kirsten; Maass, Martina; Dizayee, Sara; Leiss, Veronika; Annala, Suvi; Köth, Jessica; Seemann, Wiebke K; Müller-Ehmsen, Jochen; Mohr, Klaus; Nürnberg, Bernd; Engelhardt, Stefan; Herzig, Stefan; Birnbaumer, Lutz; Matthes, Jan 
Titel:
Lack of G?i2 leads to dilative cardiomyopathy and increased mortality in ?1-adrenoceptor overexpressing mice. 
Abstract:
Inhibitory G (Gi) proteins have been proposed to be cardioprotective. We investigated effects of G?i2 knockout on cardiac function and survival in a murine heart failure model of cardiac ?1-adrenoceptor overexpression.?1-transgenic mice lacking G?i2 (?1-tg/G?i2 (-/-)) were compared with wild-type mice and littermates either overexpressing cardiac ?1-adrenoceptors (?1-tg) or lacking G?i2 (G?i2 (-/-)). At 300 days, mortality of mice only lacking G?i2 was already higher compared with wild-type or ?...    »
 
Zeitschriftentitel:
Cardiovasc Res 
Jahr:
2015 
Band / Volume:
108 
Heft / Issue:
Seitenangaben Beitrag:
348-56 
Sprache:
eng 
Print-ISSN:
0008-6363 
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie