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Dokumenttyp:
journal article 
Autor(en):
Kretner, Benedikt; Trambauer, Johannes; Fukumori, Akio; Mielke, Janina; Kuhn, Peer-Hendrik; Kremmer, Elisabeth; Giese, Armin; Lichtenthaler, Stefan F; Haass, Christian; Arzberger, Thomas; Steiner, Harald 
Titel:
Generation and deposition of A?43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease. 
Abstract:
As stated by the prevailing amyloid cascade hypothesis, Alzheimer's disease (AD) is caused by the aggregation and cerebral deposition of long amyloid-? peptide (A?) species, which are released from a C-terminal amyloid precursor protein fragment by ?-secretase. Mutations in its catalytic subunit presenilin-1 (PS1) increase the A?42 to A?40 ratio and are the major cause of familial AD (FAD). An opposing hypothesis states that loss of essential presenilin functions underlies the disease. A major a...    »
 
Zeitschriftentitel:
EMBO Mol Med 
Jahr:
2016 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
458-65 
Sprache:
eng 
Print-ISSN:
1757-4676 
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie