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Dokumenttyp:
journal article 
Autor(en):
Budczies, Jan; Pfarr, Nicole; Stenzinger, Albrecht; Treue, Denise; Endris, Volker; Ismaeel, Fakher; Bangemann, Nikola; Blohmer, Jens-Uwe; Dietel, Manfred; Loibl, Sibylle; Klauschen, Frederick; Weichert, Wilko; Denkert, Carsten 
Titel:
Ioncopy: a novel method for calling copy number alterations in amplicon sequencing data including significance assessment. 
Abstract:
Recently, it has been demonstrated that calling of copy number alterations (CNAs) from amplicon sequencing (AS) data is feasible. Most approaches, however, require non-tumor (germline) DNA for data normalization. Here, we present the method Ioncopy for CNA detection which requires no normal controls and includes a significance assessment for each detected alteration.Ioncopy was evaluated in a cohort of 184 clinically annotated breast carcinomas. A total number of 252 amplifications were detected...    »
 
Zeitschriftentitel:
Oncotarget 
Jahr:
2016 
Band / Volume:
Heft / Issue:
11 
Seitenangaben Beitrag:
13236-47 
Sprache:
eng 
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie