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Dokumenttyp:
journal article 
Autor(en):
Bayo, Pilar; Jou, Adriana; Stenzinger, Albrecht; Shao, Chunxuan; Gross, Madeleine; Jensen, Alexandra; Grabe, Niels; Mende, Christel Herold; Rados, Pantelis Varvaki; Debus, Juergen; Weichert, Wilko; Plinkert, Peter K; Lichter, Peter; Freier, Kolja; Hess, Jochen 
Titel:
Loss of SOX2 expression induces cell motility via vimentin up-regulation and is an unfavorable risk factor for survival of head and neck squamous cell carcinoma. 
Abstract:
Recurrent gain on chromosome 3q26 encompassing the gene locus for the transcription factor SOX2 is a frequent event in human squamous cell carcinoma, including head and neck squamous cell carcinoma (HNSCC). Numerous studies demonstrated that SOX2 expression and function is related to distinct aspects of tumor cell pathophysiology. However, the underlying molecular mechanisms are not well understood, and the correlation between SOX2 expression and clinical outcome revealed conflicting data. Trans...    »
 
Zeitschriftentitel:
Mol Oncol 
Jahr:
2015 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
1704-19 
Sprache:
eng 
Print-ISSN:
1574-7891 
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie