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Dokumenttyp:
journal article 
Autor(en):
Vahle, John L; Byrd, Richard A; Blackbourne, Jamie L; Martin, Jennifer A; Sorden, Steven D; Ryan, Thomas; Pienkowski, Thomas; Rosol, Thomas J; Snyder, Paul W; Klöppel, Günter 
Titel:
Effects of the GLP-1 Receptor Agonist Dulaglutide on the Structure of the Exocrine Pancreas of Cynomolgus Monkeys. 
Abstract:
Clinical and nonclinical studies have implicated glucagon-like peptide-1 (GLP-1) receptor agonist therapy as a risk factor for acute pancreatitis in patients with type 2 diabetes. Therefore, it is critical to understand the effect that dulaglutide, an approved GLP-1 receptor agonist, has on the exocrine pancreas. Dulaglutide 8.15 mg/kg (approximately 500 times the maximum recommended human dose based on plasma exposure) was administered twice weekly for 12 months to cynomolgus monkeys. Serum amy...    »
 
Zeitschriftentitel:
Toxicol Pathol 
Jahr:
2015 
Band / Volume:
43 
Heft / Issue:
Seitenangaben Beitrag:
1004-14 
Sprache:
eng 
Print-ISSN:
0192-6233 
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie