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Dokumenttyp:
journal article 
Autor(en):
Jesinghaus, Moritz; Wolf, Thomas; Pfarr, Nicole; Muckenhuber, Alexander; Ahadova, Aysel; Warth, Arne; Goeppert, Benjamin; Sers, Christine; Kloor, Matthias; Endris, Volker; Stenzinger, Albrecht; Weichert, Wilko 
Titel:
Distinctive Spatiotemporal Stability of Somatic Mutations in Metastasized Microsatellite-stable Colorectal Cancer. 
Abstract:
A multistep model of disease progression and genomic landscape has been firmly established for colorectal cancer (CRC) primaries, but the genetic makeup of related metastases and the dynamics of genetic changes during metastatic progression are scarcely known. To address these issues, we used multigene high-coverage next-generation sequencing of 24 microsatellite-stable CRC primaries, matched normal tissue, and related multiple metastases to nodes, liver, lung, and brain with a CRC-specific gene...    »
 
Zeitschriftentitel:
Am J Surg Pathol 
Jahr:
2015 
Band / Volume:
39 
Heft / Issue:
Seitenangaben Beitrag:
1140-7 
Sprache:
eng 
Print-ISSN:
0147-5185 
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie