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Dokumenttyp:
journal article 
Autor(en):
Zinke, Jenny; Schneider, Fabian T; Harter, Patrick N; Thom, Sonja; Ziegler, Nicole; Toftgård, Rune; Plate, Karl H; Liebner, Stefan 
Titel:
?-Catenin-Gli1 interaction regulates proliferation and tumor growth in medulloblastoma. 
Abstract:
The Wnt/beta-catenin and the Hedgehog (Hh) pathway interact in various cell types while eliciting opposing or synergistic cellular effects. Both pathways are known as exclusive drivers of two distinct molecular subtypes of medulloblastoma (MB). In sonic hedgehog (Shh)-driven MB, activation of Wnt signaling has been shown to suppress tumor growth by either beta-catenin-dependent or -independent inhibition of Shh signaling. However, mechanistic insight in how beta-catenin inhibits the Hh pathway i...    »
 
Zeitschriftentitel:
Mol Cancer 
Jahr:
2015 
Band / Volume:
14 
Heft / Issue:
Seitenangaben Beitrag:
17 
Sprache:
eng 
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie