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Dokumenttyp:
journal article 
Autor(en):
Tübel, Jutta; Kuntz, Lara; Marthen, Carmen; Schmitt, Andreas; Wiest, Irmi; VON Eisenhart-Rothe, Rüdiger; Jeschke, Udo; Burgkart, Rainer 
Titel:
Methylation of the ER-alpha Promoter Is Influenced by its Ligand Estrogen in Osteosarcoma Cells SAOS-2 In Vitro. 
Abstract:
The aggressive fast-growing osteosarcoma is the most common primary malignant bone tumor. The relevance of estrogen as a key player in bone metabolism and bone tumor is well-known. At the molecular level, estrogen activates the estrogen receptor ? (ER?) as a natural ligand of this receptor. ER? acts as a transcription factor by binding to the "estrogen response element" (ERE) and regulates the expression of a various number of genes. Epigenetic processes, e.g. the methylation of the "cytosine-ph...    »
 
Zeitschriftentitel:
Anticancer Res 
Jahr:
2016 
Band / Volume:
36 
Heft / Issue:
Seitenangaben Beitrag:
3199-204 
Sprache:
eng 
Print-ISSN:
0250-7005 
TUM Einrichtung:
Orthopädische und Sportorthopädische Klinik und Poliklinik