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Document type:
journal article 
Author(s):
Hotz, Christian; Roetzer, Laurin C; Huber, Thomas; Sailer, Andreas; Oberson, Anne; Treinies, Marina; Heidegger, Simon; Herbst, Tina; Endres, Stefan; Bourquin, Carole 
Title:
TLR and RLR Signaling Are Reprogrammed in Opposite Directions after Detection of Viral Infection. 
Abstract:
Innate immune recognition of RNA is key for the initiation of immunity in response to viral infection. Although the factors controlling the detection of viral RNA by innate immune receptors in host cells are increasingly well understood, little is known about the dynamic changes in signaling after the initial triggering of these receptors. In this study, we report that preconditioning with the synthetic dsRNA polyinosinic-polycytidylic acid [poly(I:C)], a mimetic of viral RNA, rapidly reprograms...    »
 
Journal title abbreviation:
J Immunol 
Year:
2015 
Journal volume:
195 
Journal issue:
Pages contribution:
4387-95 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0022-1767 
TUM Institution:
Abteilung für Neuroradiologie