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Dokumenttyp:
journal article 
Autor(en):
Hotz, Christian; Roetzer, Laurin C; Huber, Thomas; Sailer, Andreas; Oberson, Anne; Treinies, Marina; Heidegger, Simon; Herbst, Tina; Endres, Stefan; Bourquin, Carole 
Titel:
TLR and RLR Signaling Are Reprogrammed in Opposite Directions after Detection of Viral Infection. 
Abstract:
Innate immune recognition of RNA is key for the initiation of immunity in response to viral infection. Although the factors controlling the detection of viral RNA by innate immune receptors in host cells are increasingly well understood, little is known about the dynamic changes in signaling after the initial triggering of these receptors. In this study, we report that preconditioning with the synthetic dsRNA polyinosinic-polycytidylic acid [poly(I:C)], a mimetic of viral RNA, rapidly reprograms...    »
 
Zeitschriftentitel:
J Immunol 
Jahr:
2015 
Band / Volume:
195 
Heft / Issue:
Seitenangaben Beitrag:
4387-95 
Sprache:
eng 
Print-ISSN:
0022-1767 
TUM Einrichtung:
Abteilung für Neuroradiologie