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Dokumenttyp:
journal article 
Autor(en):
Noelker, Carmen; Lu, Lixia; Höllerhage, Matthias; Vulinovic, Franca; Sturn, Annekathrin; Roscher, René; Höglinger, Günter U; Hirsch, Etienne C; Oertel, Wolfgang H; Alvarez-Fischer, Daniel; Andreas, Hartmann 
Titel:
Glucocerebrosidase deficiency and mitochondrial impairment in experimental Parkinson disease. 
Abstract:
Gaucher disease is an autosomal recessive disease, caused by a lack or functional deficiency of the lysosomal enzyme, glucocerebrosidase (GCase). Recently, mutations in the glucocerebrosidase gene (GBA) have been associated with Parkinson's disease (PD) and GBA mutations are now considered the most important genetic vulnerability factor for PD. In this study, we have investigated (i) in vivo whether inhibition of the enzyme glucosylceramide synthase by miglustat may protect C57Bl/6 mice against...    »
 
Zeitschriftentitel:
J Neurol Sci 
Jahr:
2015 
Band / Volume:
356 
Heft / Issue:
1-2 
Seitenangaben Beitrag:
129-36 
Sprache:
eng 
Print-ISSN:
0022-510X 
TUM Einrichtung:
Neurologische Klinik und Poliklinik