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Dokumenttyp:
journal article 
Autor(en):
Nischwitz, S; Wolf, C; Andlauer, T F M; Czamara, D; Zettl, U K; Rieckmann, P; Buck, D; Ising, M; Bettecken, T; Mueller-Myhsok, B; Weber, F 
Titel:
MS susceptibility is not affected by single nucleotide polymorphisms in the MMP9 gene. 
Abstract:
Matrix metalloproteinase 9 (MMP9) plays an important role in the pathogenesis of multiple sclerosis (MS). However, the impact of genetic variants affecting MMP9 on MS susceptibility is still in debate. We could not detect an association of MMP9 SNPs with MS on a genome-wide significance level by SNP genotyping, followed by imputation of SNPs within a region stretching 2Mbp up- and down-stream of MMP9. Rs6073751, located within WFDC2, was found associated with MS most strongly. Rs3918242, associa...    »
 
Zeitschriftentitel:
J Neuroimmunol 
Jahr:
2015 
Band / Volume:
279 
Seitenangaben Beitrag:
46-9 
Sprache:
eng 
Print-ISSN:
0165-5728 
TUM Einrichtung:
Neurologische Klinik und Poliklinik