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Document type:
journal article 
Author(s):
Keller, Birgit; Mühlenkamp, Melanie; Deuschle, Eva; Siegfried, Alexandra; Mössner, Sara; Schade, Jessica; Griesinger, Tanja; Katava, Nenad; Braunsdorf, Christina; Fehrenbacher, Birgit; Jiménez-Soto, Luisa F; Schaller, Martin; Haas, Rainer; Genth, Harald; Retta, Saverio F; Meyer, Hannelore; Böttcher, Ralph T; Zent, Roy; Schütz, Monika; Autenrieth, Ingo B; Bohn, Erwin 
Title:
Yersinia enterocolitica exploits different pathways to accomplish adhesion and toxin injection into host cells. 
Abstract:
The current paradigm suggests that Yersinia enterocolitica (Ye) adheres to host cells via the outer membrane proteins Yersinia adhesin A (YadA) or invasin (Inv) to facilitate injection of Yops by the type III secretion system. In this process Inv binds directly to ?1 integrins of host cells while YadA may bind indirectly via extracellular matrix proteins to ?1 integrins. Here we challenged this paradigm and investigated the requirements for Yop injection. We demonstrate that Inv- but not YadA-me...    »
 
Journal title abbreviation:
Cell Microbiol 
Year:
2015 
Journal volume:
17 
Journal issue:
Pages contribution:
1179-204 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
1462-5814 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene