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Dokumenttyp:
journal article 
Autor(en):
Dufner, Almut; Kisser, Agnes; Niendorf, Sandra; Basters, Anja; Reissig, Sonja; Schönle, Anne; Aichem, Annette; Kurz, Thorsten; Schlosser, Andreas; Yablonski, Deborah; Groettrup, Marcus; Buch, Thorsten; Waisman, Ari; Schamel, Wolfgang W; Prinz, Marco; Knobeloch, Klaus-Peter 
Titel:
The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells. 
Abstract:
The modification of proteins by ubiquitin has a major role in cells of the immune system and is counteracted by various deubiquitinating enzymes (DUBs) with poorly defined functions. Here we identified the ubiquitin-specific protease USP8 as a regulatory component of the T cell antigen receptor (TCR) signalosome that interacted with the adaptor Gads and the regulatory molecule 14-3-3?. Caspase-dependent processing of USP8 occurred after stimulation of the TCR. T cell-specific deletion of USP8 in...    »
 
Zeitschriftentitel:
Nat Immunol 
Jahr:
2015 
Band / Volume:
16 
Heft / Issue:
Seitenangaben Beitrag:
950-60 
Sprache:
eng 
Print-ISSN:
1529-2908 
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene