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Document type:
journal article 
Author(s):
Belting, Lena; Hömberg, Nadine; Przewoznik, Margarethe; Brenner, Christoph; Riedel, Tanja; Flatley, Andrew; Poli?, Bojan; Busch, Dirk H; Röcken, Martin; Mocikat, Ralph 
Title:
Critical role of the NKG2D receptor for NK cell-mediated control and immune escape of B-cell lymphoma. 
Abstract:
Little is known on the control of lymphomas by NK cells. Here, we study the role of the NK group 2D (NKG2D) receptor for the immunosurveillance of lymphoma. By using transplantable tumors as well as a ?-myc-transgenic model of endogenously arising lymphoma and NKG2D-deficient mice, we show that NK cells eliminate tumor cells in vivo after receiving two signals. One step involved the activation of NK cells giving rise to IFN-? expression, which was effected by MHCI(low) tumor cells or DCs. Howeve...    »
 
Journal title abbreviation:
Eur J Immunol 
Year:
2015 
Journal volume:
45 
Journal issue:
Pages contribution:
2593-601 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0014-2980 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene