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Document type:
journal article 
Author(s):
Agelopoulos, Konstantin; Richter, Günther H S; Schmidt, Eva; Dirksen, Uta; von Heyking, Kristina; Moser, Benjamin; Klein, Hans-Ulrich; Kontny, Udo; Dugas, Martin; Poos, Kathrin; Korsching, Eberhard; Buch, Thorsten; Weckesser, Matthias; Schulze, Isabell; Besoke, Regina; Witten, Anika; Stoll, Monika; Köhler, Gabriele; Hartmann, Wolfgang; Wardelmann, Eva; Rossig, Claudia; Baumhoer, Daniel; Jürgens, Heribert; Burdach, Stefan; Berdel, Wolfgang E; Müller-Tidow, Carsten 
Title:
Deep Sequencing in Conjunction with Expression and Functional Analyses Reveals Activation of FGFR1 in Ewing Sarcoma. 
Abstract:
A low mutation rate seems to be a general feature of pediatric cancers, in particular in oncofusion gene-driven tumors. Genetically, Ewing sarcoma is defined by balanced chromosomal EWS/ETS translocations, which give rise to oncogenic chimeric proteins (EWS-ETS). Other contributing somatic mutations involved in disease development have only been observed at low frequency.Tumor samples of 116 Ewing sarcoma patients were analyzed here. Whole-genome sequencing was performed on two patients with nor...    »
 
Journal title abbreviation:
Clin Cancer Res 
Year:
2015 
Journal volume:
21 
Journal issue:
21 
Pages contribution:
4935-46 
Language:
eng 
Print-ISSN:
1078-0432 
TUM Institution:
Kinderklinik und Poliklinik; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene