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Dokumenttyp:
journal article 
Autor(en):
Franke, Katharina; Vilne, Baiba; Prazeres da Costa, Olivia; Rudelius, Martina; Peschel, Christian; Oostendorp, Robert A J; Keller, Ulrich 
Titel:
In vivo hematopoietic Myc activation directs a transcriptional signature in endothelial cells within the bone marrow microenvironment. 
Abstract:
Cancer pathogenesis involves tumor-intrinsic genomic aberrations and tumor-cell extrinsic mechanisms such as failure of immunosurveillance and structural and functional changes in the microenvironment. Using Myc as a model oncogene we established a conditional mouse bone marrow transduction/transplantation model where the conditional activation of the oncoprotein Myc expressed in the hematopoietic system could be assessed for influencing the host microenvironment. Constitutive ectopic expression...    »
 
Zeitschriftentitel:
Oncotarget 
Jahr:
2015 
Band / Volume:
Heft / Issue:
26 
Seitenangaben Beitrag:
21827-39 
Sprache:
eng 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik