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Dokumenttyp:
journal article 
Autor(en):
Oostendorp, Robert A J 
Titel:
Secretion of Wnts is dispensable for hematopoiesis. 
Abstract:
In this issue of Blood, Kabiri and coworkers report the hematopoietic deletion of the endoplasmic reticulum-localized O-acyltransferase porcupine (PORCN), which is necessary for acylation of Wnts in the endoplasmic reticulum, enabling their secretion and binding to the frizzled receptors. Unexpectedly, the absence of secreted Wnt factors does not have major effects on steady-state in vivo hematopoiesis or on long-term repopulating activity of Wnt-deficient hematopoietic stem cells. 
Zeitschriftentitel:
Blood 
Jahr:
2015 
Band / Volume:
126 
Heft / Issue:
Seitenangaben Beitrag:
1051-2 
Sprache:
eng 
Print-ISSN:
0006-4971 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik