Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Wünsch, Désirée; Hahlbrock, Angelina; Heiselmayer, Christina; Bäcker, Sandra; Heun, Patrick; Goesswein, Dorothee; Stöcker, Walter; Schirmeister, Tanja; Schneider, Günter; Krämer, Oliver H; Knauer, Shirley K; Stauber, Roland H 
Titel:
Fly versus man: evolutionary impairment of nucleolar targeting affects the degradome of Drosophila's Taspase1. 
Abstract:
Human Taspase1 is essential for development and cancer by processing critical regulators, such as the mixed-lineage leukemia protein. Likewise, its ortholog, trithorax, is cleaved by Drosophila Taspase1 (dTaspase1), implementing a functional coevolution. To uncover novel mechanism regulating protease function, we performed a functional analysis of dTaspase1 and its comparison to the human ortholog. dTaspase1 contains an essential nucleophile threonine(195), catalyzing cis cleavage into its ?- an...    »
 
Zeitschriftentitel:
FASEB J 
Jahr:
2015 
Band / Volume:
29 
Heft / Issue:
Seitenangaben Beitrag:
1973-85 
Sprache:
eng 
Print-ISSN:
0892-6638 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik