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Dokumenttyp:
journal article 
Autor(en):
Sibaev, Andrei; Fichna, Jakub; Saur, Dieter; Yuece, Birol; Timmermans, Jean-Pierre; Storr, Martin 
Titel:
Nociceptin effect on intestinal motility depends on opioid-receptor like-1 receptors and nitric oxide synthase co-localization. 
Abstract:
To study the effect of the opioid-receptor like-1 (ORL1) agonist nociceptin on gastrointestinal (GI) myenteric neurotransmission and motility.Reverse transcriptase - polymerase chain reaction and immunohistochemistry were used to localize nociceptin and ORL1 in mouse tissues. Intracellular electrophysiological recordings of excitatory and inhibitory junction potentials (EJP, IJP) were made in a chambered organ bath. Intestinal motility was measured in vivo.Nociceptin accelerated whole and upper...    »
 
Zeitschriftentitel:
World J Gastrointest Pharmacol Ther 
Jahr:
2015 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
73-83 
Sprache:
eng 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik